Arbetsbeskrivning

Lund University was founded in 1666 and is repeatedly ranked among the world’s top universities. The University has around 46 000 students and 8 500 staff based in Lund, Helsingborg and Malmö. We are united in our efforts to understand, explain and improve our world and the human condition.

Lund University welcomes applicants with diverse backgrounds and experiences. We regard equality, equal opportunities and diversity as a strength and an asset.

Description of workplace

The Molecular Neuroanatomy research group, led by Åsa Mackenzie, investigates the brain regions and neural circuits involved in the motor and non-motor symptoms of Parkinson’s disease. The group combines anatomical, molecular and functional approaches, with a particular focus on the subthalamic nucleus (STN), an important target for deep brain stimulation (DBS) in Parkinson’s disease.

We are now seeking a Postdoctoral Researcher to join an experimental research project investigating the organisation and function of brain circuits relevant to Parkinson’s disease.

We offer

Lund University is a governmental authority, which means you get special benefits, generous holidays, and a favorable occupational pension. Read more on the university's website about being employed at Lund University, Work at Lund University

Work description

The overarching aim is to characterise the molecular and anatomical organisation of the human subthalamic region and investigate the functional relevance of selected neural populations using optogenetic approaches in mice.

The work is primarily laboratory-based and involves hands-on experimental research, including:

• Molecular and anatomical mapping: Histological analysis of human, mouse and macaque brain tissue using techniques such as in situ hybridisation and immunohistochemistry, followed by microscopy, image analysis and spatial reconstruction.
• Optogenetic and behavioural studies: PCR-based genotyping, stereotactic brain surgery, viral vector delivery and optical fibre implantation, optogenetic manipulation of neural circuits, and behavioural assessment in mouse models relevant to Parkinson’s disease.
• Molecular and spatial data integration: Integration of histological and molecular findings with existing MRI-based anatomical datasets and DBS stimulation data from clinical and preclinical studies.
• Research communication and collaboration: Analysis, interpretation and presentation of research findings, including preparation of scientific manuscripts and presentations at national and international meetings.

Basis for assessment

This is a merit-based position primarily focused on research. The position is intended as an initial step in the academic career, and the selection will be based primarily on scientific merit and potential as a researcher. Particular emphasis will be placed on demonstrated scientific skills within the subject area.

For postdoctoral appointments, the following shall form the basis for assessment:

• Proven ability to develop and conduct high-quality research

Additional qualifications will be assessed based on the following requirements for the position:

• PhD in neurobiology, experimental psychology, pharmacology or a related discipline.
• Documented practical research experience in experimental neuroscience, including relevant histological and/or molecular techniques.
• Practical experience in at least some of the following: optogenetics, behavioral analysis, stereotactic surgery and molecular genotyping.
• FELASA-accredited training, or equivalent qualifications, for work with laboratory animals.
• Ability to work independently, take initiative and demonstrate strong scientific and technical competence.

Meritorious qualifications:

• Experience in optogenetic manipulation and behavioural studies in mouse models.
• Experience in stereotactic brain surgery, viral vector delivery and optical fibre implantation.
• Experience in molecular neuroanatomy, in situ hybridisation and immunohistochemistry.
• Experience in comparative neuroanatomy, particularly involving human and non-human primate brain tissue.
• Experience in microscopy, advanced image analysis and spatial reconstruction.
• Experience integrating histological findings with MRI-based anatomical data or DBS-related data.
• Previous postdoctoral or other relevant research experience.
• Demonstrated ability to communicate research findings through scientific publications and oral presentations.
• Experience in scientific writing and preparation of manuscripts for publication.

Eligibility

Appointment to a post-doctoral position requires that the applicant has a PhD, or an international degree deemed equivalent to a PhD, within the subject of the position. This eligibility requirement needs to be met no later than the time when the employment decision is made. We will mainly consider candidates who have completed their PhD degree no more than three (3) years before the last date for applications.

Terms of employment

This is a full-time employment limited to 2 years, with the possibility of extension for up to one additional year. Preliminary start is the 11th of January 2027, or according to agreement. The period of employment is determined in accordance with the agreement “Avtal om tidsbegränsad anställning som postdoktor” between SACO-S, OFR/S and SEKO, dated November 19, 2021.

How to apply

The position is sought via the university's recruitment system. The application must include a personal letter (maximum two pages) in which you describe how you meet the qualification requirements and why you are interested in the position. The application must also contain a CV, including a list of publications, a general description of previous research work (maximum one page), a copy of the doctorate and anything else you wish to refer to (copies of diplomas, grades, information for references, letters of recommendation, etc.) as well as contact information for two references.