Arbetsbeskrivning

Our Genome Engineering Team in Gothenburg, Sweden focuses on developing treatment for Rare Diseases. We continually push the boundaries of science to expand the limits of scientific research to better understand rare diseases, discover new life-changing treatments and deliver medicines to patients. As a Senior Research Scientist, you will be a key member of the Genome Engineering Department. You will join our international team that develops novel genome engineering technologies and applies these breakthroughs to generate innovative gene therapies. We provide a stimulating environment with state-of-the-art facilities where you can transform cutting-edge genome engineering tools into effective and safe medicines. About the position In this laboratory-based role, you will leverage your scientific expertise in genome engineering and innovative thinking to develop novel tools and applications that can lead to breakthrough therapies. As a key member of cross-functional project teams, you will develop and evaluate genome editing strategies for specific disease projects. Accountabilities will include innovative optimization of genome engineering technologies to facilitate effective gene editing in target cell & tissue types, developing relevant assays, analysing gene editing outcomes, documenting, interpreting, and communicating results to appropriate partners. Reponsibilities • Designing and evaluating therapeutic genome editing strategies for specific disease indications • Optimization of genome engineering technologies to facilitate effective gene editing in target cell & tissue types • Developing and routinely running appropriate assays for evaluating gene editing outcomes • Documenting, interpreting and communicating results to stakeholders and partners Your profile Essential for the role:? • PhD degree in life sciences or relevant areas with strong wet-lab skills, or MSc degree with equivalent experience • Strong skills in working with mammalian cell models (immortalized or primary) • Understanding and previous hands-on experience with CRISPR-Cas9 technologies • Strong skillset in standard molecular biology techniques in analyzing DNA, RNA and protein (e.g. PCR, sequencing technologies, RNA extraction, qPCR, Western blot, ELISA) • Strong communication skills, scientific rigor and ethics, ability to effectively work independently and collaboratively in a team Desirable for the role:? • Experience working with lentiviral vector for engineering cell models • Experience with using liquid handling instruments • Experience with optimizing genome editing technologies (construct design, gRNA optimization, delivery) or equivalent protein engineering expertise About the Organisation This is a consultant assignment at AstraZeneca in Göteborg from April until end of March 2027. During the time you will be hired by QRIOS. Please apply by registering your CV here on our website. Click on the "Ansök" button to the right. It is our recommendation that you register as much information as possible and that you attach a complete CV-document. Please check that your correct e-mail address is registered.