Arbetsbeskrivning

We are offering two exciting PhD positions to explore the fascinating world of DNA and RNA at the single-molecule level using optical tweezers. By delving into their thermodynamics, kinetics, and dynamics, you will uncover how these biomolecules function and interact with small molecules, including potential drug candidates. The project is part of a European doctoral network consisting of in total 15 PhD students and includes common courses and secondments in other labs. Information about the division and the department The Chemical Biology division is the home of seven research groups. We combine and develop protein engineering, synthetic chemistry and state-of-the-art biophysical methos (spectroscopy, live-cell imaging and nanotechnology) to address cutting edge questions in biology to meet medical challenges related to human health. Our joint expertise spans from molecular biophysics of single molecules to cell and organism biology. The Westerlund group uses single molecule techniques to single molecules with a strong focus on nucleic acids. The research ranges from basic science to clinical and diagnostic applications. Within this project we will collaborate with several European groups on using optical tweezers to study single DNA and RNA molecules. Project description The positions are part of a European doctoral network (MSCA-DN) consisting of in total 15 PhD students in 8 universities in 6 countries. The two students will work with optical tweezers to study nucleic acids and their interactions with small molecules, complemented by other biophysical techniques. The goal is to understand how to develop next generation therapeutics based on nucleic acids and their interactions. The international context of the project means that you will spend time in at least two other labs as part of the PhD studies. Major responsibilities • Single molecule experiments using optical tweezers,  • Collaborations with several European groups,  • Secondments in at least two complementary labs. Read more about doctoral studies at Chalmers here. Qualifications To qualify for this position you must have:  • Master’s Degree in biophysics or similar; • Experience in nucleic acids analysis; • Experience in data analysis in Matlab, R or similar.  Due to the MSCA-DN regulations, you cannot have spent more than 12 of the last 36 months studying or working in Sweden to be qualified for the position.  Contract terms Full-time temporary employment. The position is limited to a maximum of five years. We offer Chalmers offers a cultivating and inspiring working environment in the coastal city of Gothenburg.  Read more about working at Chalmers and our benefits for employees. Chalmers aims to actively improve our gender balance. We work broadly with equality projects, for example the GENIE Initiative on gender equality for excellence. Equality and diversity are substantial foundations in all activities at Chalmers. Application procedure Submit your application in English, as PDF files (max 40 MB each; ZIP files not supported). CV (Name file: CV, Family Name): • CV, • Previous employment, leadership roles, or positions of trust, • Contact details for two references. Personal Letter (Name file: Personal Letter, Family Name): • Introduce yourself and your relevant experience (e.g., education, thesis work, or research), • Outline your goals and research focus (1-3 pages). Additional Documents: • Copies of bachelor and/or master’s thesis, • Certified transcripts, grades, and certificates (e.g., TOEFL). Use the button at the foot of the page to reach the application form.  Please note: The applicant is responsible for ensuring that the application is complete. Incomplete applications and applications sent by email will not be considered. Application deadline: January 10, 2025  For questions about the research project, please contact: Professor Fredrik Westerlund Email: [email protected] *** Chalmers declines to consider all offers of further announcement publishing or other types of support for the recruiting process in connection with this position. ***      Chalmers University of Technology in Gothenburg conducts research and education in technology and natural sciences at a high international level. The university has 3100 employees and 10,000 students, and offers education in engineering, science, shipping and architecture. With scientific excellence as a basis, Chalmers promotes knowledge and technical solutions for a sustainable world. Through global commitment and entrepreneurship, we foster an innovative spirit, in close collaboration with wider society. Chalmers was founded in 1829 and has the same motto today as it did then: Avancez – forward.