Job description

Are you a motivated cell biologist with experience of in vitro work in molecular biology, omics and oligonucleotides? Do you also enjoy working hands-on in the lab with a great group of colleagues by your side? If yes, this might be the next position for you!

Right now, we are looking for a highly engaged and enthusiastic cell biologist to join as a Discovery Safety Scientist and complement us in our In Vitro Safety group at AstraZeneca in Gothenburg, Sweden. The ideal candidate will have a passion for in vitro lab based experimentation and analysis and value the utility of early drug safety investigations. We are looking for someone with strong communication and collaboration drive, who can adopt a brave and forward-thinking approach to drive our predictive in vitro safety assay design to support drug discovery and development projects.

Why AstraZeneca?

We are working towards treating, preventing, modifying and even curing some of the world’s most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

Does this sound like your next challenge? Apply today!

This is a consulting assignment with Randstad Life Sciences. Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Deadline: 2024-06-11 selection and interviews will be ongoing. For more information: Please contact Malin Fridholm, [email protected]

Responsibilities

What you’ll do:

Working in an industry-leading in vitro safety lab you will work with internal research groups to identify potential off-target risks for siRNA/antisense oligonucleotide (ASO) projects. Develop in vitro assays to explore those potential off targets in a variety of different mammalian cell types via gene expression analysis. You will also be required to summarize safety related literature relating to modulation of off-target genes to help inform decisions and support the development of safer oligonucleotide-based drug products.

Qualifications

Essential for the role:

• PhD in biology, biotechnology, toxicology or pharmacology or a related field.
• Strong background in mammalian cell biology and in vitro work in molecular biology & omics including gene expression modulation via siRNA/ASOs and qPCR measurements. Additional in vitro techniques would be advantageous including fluidigm qPCR, high content cell imaging, western blot, ELISA & FACs.
• Experience of complex in vitro cell models or MPS systems would be desirable.
• Track record of scientific literature review with an ability to pull together various sources of data to inform on potential safety questions & targets of interest.
• Strong communication skills: including presenting, communicating data analysis, influencing and building partnerships with internal and external research groups.

About the company

Randstad

At Randstad, we see the possible in people. With business all over Sweden and in all areas of expertise, we help people find work that feels good, where they get the opportunity to develop and realize their true potential.

With close to 600 000 employees in 38 countries, Randstad is the global leader in the HR services industry. Our mission is to become the world’s most valued working life partner. By combining our passion for people with the power of today’s technology, we support people and organizations in realizing their true potential. We call it Human Forward.